Juvenile chronic myelogenous leukemia (JCML)
نویسندگان
چکیده
منابع مشابه
Cytogenetic features of juvenile chronic myelogenous leukemia.
Consistent chromosomal abnormalities have been described in several leukemic disorders, but relatively little is known about the cytogenetic features of juvenile chronic myelogenous leukemia (JCML). We report the serial cytogenetic findings over a 2-yr period for a patient with JCML. A large subtelocentric marker chromosome was noted in all metaphases throughout the course of his disease and pr...
متن کاملClonality in juvenile chronic myelogenous leukemia.
Juvenile chronic myelogenous leukemia (JCML) is a myeloproliferative disease in which morbidity and mortality are primarily caused by nonhematopoietic organ failure from myelomonocytic infiltration or by failure of the normal bone marrow. Morphologic evidence of maturation arrest, karyotypic abnormalities, and progression to blast crisis are infrequent events. Viral infections and other reactiv...
متن کاملJuvenile chronic myelogenous leukemia: therapeutic trial with interferon alpha 2B.
Juvenile chronic myelogenous leukemia (JCML) is a rare malignant hematopoietic disorder representing only 2% of all childhood leukemias. The disease has a rapid course and has a median survival of less than 10 months when untreated or undertreated(l,2). Patients are often difficult to diagnose because of their clinical heterogeneity. A remarkable feature is increased synthesis of HbF and excess...
متن کاملClonal origin of erythroid cells in juvenile chronic myelogenous leukemia.
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متن کاملFlow Cytometry in Chronic Myelogenous Leukemia Blast Crisis
Background: Chronic myelogenous leukemia (CML) is a myeloproliferative disorder due to BCR-ABL1 translocation. Patients showing transformation into blast crisis (BC) have poorer treatment response and prognosis. Methods: A retrospective study was conducted in the department of Pathology, Maulana Azad Medical College, New Delhi, India, over a time period of 5 years (2014-2019) to evaluate the ...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/37702